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The Science of Saving Lives: Latest Research on Suicide Prevention

Suicide prevention has evolved from single interventions to comprehensive, evidence-based strategies. Here’s what the latest research reveals about what actually works and what doesn’t.

What Works: The Evidence-Based Foundation

Safety Planning Replaces Outdated Approaches

The biggest shift in suicide prevention is the move from “no-suicide contracts” to collaborative safety planning. Research shows no-suicide contracts lack efficacy, while safety planning actually saves lives. Safety planning involves individuals identifying their warning signs, coping strategies, support people, and ways to restrict access to lethal means. This approach empowers individuals rather than simply extracting promises.

Proven Therapies

Cognitive behavioral therapy (CBT) and dialectical behavior therapy (DBT) demonstrate significant reductions in both suicidal ideation and actual attempts compared to standard treatment. Lithium continues to reduce suicide rates in patients with mood disorders. Ketamine shows promise for rapidly reducing suicidal ideation, though its effect on actual attempts needs more research.

Digital Innovation: Promise with Limitations

Electronic health record algorithms and smartphone monitoring can identify high-risk individuals and achieve small, short-term reductions in suicidal thoughts. However, current research shows these digital tools don’t effectively reduce actual suicide attempts or deaths.The main challenge isn’t identifying risk but rather having proven interventions ready for those identified as high-risk. Patient engagement tools can augment this process by facilitating connection and follow-up care, but ultimately effective suicide prevention depends on human action and clinical response, not just technological identification. Digital tools work best as supplements to, not replacements for, established interventions delivered by trained professionals.

 

The Systems Approach

Effective prevention requires collaboration across healthcare, communities, and policy levels. The U.S. National Strategy emphasizes addressing social determinants like economic instability and healthcare access alongside clinical interventions.

Bottom Line

Suicide prevention works through layered approaches combining:

  • Safety planning interventions
  • Evidence-based psychotherapies (CBT, DBT)
  • Means restriction counseling
  • Brief interventions with follow-up care
  • System-level strategies

The science is clear: when we implement evidence-based suicide prevention strategies systematically, we prevent deaths. No single intervention is sufficient, but comprehensive approaches save lives. The challenge now is translating this research into widespread practice and ensuring these proven strategies reach everyone who needs them. The path forward requires sustained commitment to both clinical best practices and the systems changes needed to make life-saving interventions accessible to all.


Crisis support is available 24/7 at 988 (call, text, or chat at 988lifeline.org).

About The Author

Dr. Elise Herman is Chief Clinical Officer at Mend, where she leads clinical strategy for mental and behavioral healthcare organizations.

Connect with Dr. Herman on LinkedIn!

Mend’s Take:

The evidence is clear: technology can find risk, but people save lives. The best results come when a digital flag immediately triggers human-led, evidence-based steps: safety planning, means-restriction counseling, therapy, and reliable follow-up.

That’s exactly how we design Mend. We don’t replace your EHR—we mend the gaps between an alert and action:

Engage: Portal-free outreach and two-way texting reach patients fast; templates document collaborative safety plans and means-restriction counseling. Automated, but ultimately human-led check-ins.

Access: Concierge scheduling to convert “we should follow up” into a booked appointment. Before the moment passes.

Signal: Behavioral-health-specific dashboards that surface who needs contact today and nudge staff until the warm handoff and follow-up are done.

Fusion: One screen that lives in your EHR. Act in the workflow you already use: Start the safety plan; Message the patient; Schedule the visit; Launch a telehealth session…and never switch screens.

Digital tools should support clinicians, not stand in for them. Mend’s superpower is getting patients to take action. Get patients to answer, to schedule, to show up. And get your teams back to the life-saving work only humans can do.

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ReferenCes:

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    Practice Guideline
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